Aceso Global CEO Maureen Lewis explores the new health agenda laid out by Michael Bloomberg in his Annual Letter on Philanthropy mandated by the rapid shift in disease prevalence from infectious to non-communicable diseases (NCDs) in low- and middle-income countries. She argues that while prevention will be critical to the future fight against NCDs, as laid out by Bloomberg, a robust agenda remains for treating and managing patients currently suffering from these conditions. Effectively meeting this agenda will require not only restructuring the healthcare delivery system to meet the needs of the chronically ill, but also a shift in the international donor community’s focus to concentrate on the emerging challenge of NCDs.